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ASAP (Annotating Single-cell data matrix by Approximate Pseudo-bulk projection) in R

The goal of ASAP framework:

  1. Cell topic annotation should be reasonably fast enough to be integrated with a typical analysis pipeline.

  2. The whole algorithm should be accessible to users with modest computing resources (e.g., low memory footprint).

  3. Batch adjustment and follow-up analysis should render intuitive (causal) interpretations.